Discovering a novel drug class targeting the epitranscriptomics machinery



Gotham Therapeutics has assembled an exceptional team and network to establish a novel drug class targeting the epitranscriptomics machinery.

By changing the activity of proteins that modify messenger RNA, we aim to develop new treatment options for patients suffering from cancers, auto-immune and neurodegenerative diseases. We are applying a 360-degree approach to small molecule drug design to build a pipeline based on the promise of this rapidly emerging biopharmaceutical field.


LEE BABISS, CEO and Co-Founder

Unprecedented targets that play a key role in mRNA biology and our efforts will reveal a novel drug class targeting the epitranscriptomics machinery…

… and opening the door to now address diseases that are currently underserved. Read more about LEE >



Gotham will focus initially on targets with the most compelling links to disease…

… and move on rapidly to develop small molecule inhibitors employing diverse screening strategies coupled with state-of-the art medicinal chemistry. Read more about GERHARD >


BIRGIT ZECH, COO and Co-Founder

As the pharmaceutical industry opens up to the reality of RNA modification…

… we are seeing more companies moving into the field of epitranscriptomics as a way to address human diseases in a novel way. Read more about BIRGIT >

From #NYC to #MUC

Gotham is part of New York City’s rapidly growing biopharma community with a subsidiary in one of Europe’s leading life science clusters near Munich, Germany.

With the ability to attract talent on both sides of the Atlantic and recruit from two of the most vibrant academic talent pools in our industry, Gotham will complement its team of experts to spearhead target validation, drug discovery and development in the epitranscriptomics sector.


February 14, 2019 - Gotham Strengthens Board of Directors and Scientific Advisory Board

In February 2019, Gotham announced the appointment of Carlo Incerti, M.D., Ph.D. as an independent Board Member. In addition, the company added Thomas Tuschl, Ph.D. as a Scientific Advisor.

ChinaBio® Partnering Forum

Meet our CEO Lee Babiss at the 11th Annual ChinaBio® Partnering Forum in Shanghai, China, May 08 - 09, 2019.